A blood test can predict the worsening of which disease?
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Recent research has highlighted the potential of blood tests to predict the worsening of several diseases: * Alzheimer's Disease: A simple blood test measuring insulin resistance, specifically using the triglyceride-glucose (TyG) index, has shown promise in identifying early Alzheimer's patients atRead more
Recent research has highlighted the potential of blood tests to predict the worsening of several diseases:
See less* Alzheimer’s Disease: A simple blood test measuring insulin resistance, specifically using the triglyceride-glucose (TyG) index, has shown promise in identifying early Alzheimer’s patients at high risk of rapid cognitive decline. High TyG scores were associated with a four-fold faster decline in cognitive function. This suggests a link between metabolic dysfunction and the progression of Alzheimer’s.
* Sepsis: Canadian scientists have developed an innovative molecular-based blood test and portable device to quickly predict the risk of sepsis worsening within the first 24 hours of clinical presentation. This “Sepset” test identifies a six-gene signature that indicates the immune system is dangerously dysregulating.
* Multiple Sclerosis (MS): A new blood test can detect worsening disability in MS patients one to two years before it occurs by focusing on the biomarker neurofilament light chain (NfL). Elevated NfL levels are associated with a higher risk of worsening disability, both with and without relapses.
* Amyotrophic Lateral Sclerosis (ALS): Blood tests, particularly those measuring neurofilament light chain (NfL) proteins, can help in both diagnosing ALS and predicting how quickly the disease is likely to progress.
* Parkinson’s Disease: Researchers have developed a blood test that uses artificial intelligence (AI) to predict Parkinson’s up to seven years before the onset of symptoms by analyzing eight specific proteins in the blood.
Beyond these, research is ongoing into using blood tests to predict the risk and progression of a wide range of other conditions, including:
* Various Cancers: Multi-cancer early detection (MCED) tests are being developed to pick up chemical signals indicative of many different types of cancer, potentially thwarting progression to late stages.
* Chronic Diseases in General: A score called ICHRON (Intermountain Chronic Disease Risk Score) combines routine blood test information with a patient’s age to accurately predict the future risk of chronic diseases like kidney failure, diabetes, heart attack, and heart failure.
* Cardiovascular Disease: Various blood markers like Apolipoprotein B (ApoB), Homocysteine (Hcy), HbA1c, fasting glucose, and high-sensitivity C-reactive protein (us-CRP) can indicate the risk of coronary artery disease and other heart and blood vessel conditions.
* Organ-specific aging: A new study suggests a blood test could predict the risk of major diseases like cancer and dementia by identifying which organs are aging at different rates. For instance, accelerated lung aging was linked to a higher risk of respiratory infections, COPD, and lung cancer.
The development of these blood tests represents a significant step forward in personalized medicine, allowing for earlier identification of at-risk individuals and more targeted interventions to potentially slow or prevent disease progression.