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Ali1234Researcher

What are the symptoms of thyroid?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:21 am

    The symptoms of thyroid problems can vary greatly depending on whether your thyroid gland is producing too much hormone (hyperthyroidism) or too little (hypothyroidism). Symptoms of an Underactive Thyroid (Hypothyroidism): When your thyroid doesn't produce enough hormones, your metabolism slows downRead more

    The symptoms of thyroid problems can vary greatly depending on whether your thyroid gland is producing too much hormone (hyperthyroidism) or too little (hypothyroidism).
    Symptoms of an Underactive Thyroid (Hypothyroidism):
    When your thyroid doesn’t produce enough hormones, your metabolism slows down, leading to symptoms like:
    * Fatigue and tiredness: Feeling exhausted even after getting enough sleep.
    * Weight gain: Often unexplained, despite no changes in diet or exercise.
    * Increased sensitivity to cold: Feeling cold even in mild temperatures.
    * Constipation: Slower digestion.
    * **Dry skin and hair: Skin can be dry and scaly, and hair may become thin, coarse, or brittle.
    * Muscle aches, tenderness, and stiffness: Including muscle weakness and cramps.
    * Joint pain, stiffness, or swelling.
    * Depression and mood changes: Feeling sad, apathetic, or experiencing mood swings.
    * Memory problems and difficulty concentrating: Often described as “brain fog.”
    * Slowed heart rate (bradycardia).
    * Heavy or irregular menstrual periods.
    * Hoarse voice.
    * A puffy face or swelling in the face/legs.
    * Loss of libido (sex drive).
    * Thinning or partly missing eyebrows.
    * Carpal tunnel syndrome (pain, numbness, and tingling in the hand and fingers).
    Symptoms of an Overactive Thyroid (Hyperthyroidism):
    When your thyroid produces too much hormone, your metabolism speeds up, causing symptoms such as:
    * Unexplained weight loss: Often despite an increased appetite.
    * Rapid or irregular heartbeat (palpitations, tachycardia, or arrhythmia).
    * Nervousness, anxiety, and irritability.
    * Tremor: Usually a slight trembling in the hands and fingers.
    * Increased sweating and sensitivity to heat: Warm, moist skin.
    * Changes in bowel patterns: Especially more frequent bowel movements or diarrhea.
    * Sleep problems: Difficulty falling or staying asleep (insomnia).
    * Muscle weakness.
    * Changes in menstrual cycles: Irregular or lighter periods.
    * Enlarged thyroid gland (goiter): May appear as a swelling at the base of the neck.
    * Bulging eyes (thyroid eye disease/Graves’ ophthalmopathy): More common in Graves’ disease, an autoimmune cause of hyperthyroidism. This can also involve a gritty sensation, pressure or pain, puffy or retracted eyelids, redness, inflammation, light sensitivity, or double vision.
    * Thinning skin.
    * Fine, brittle hair.
    * Reddened palms.
    * Raised, itchy rash (hives) or discolored, swollen skin (Graves’ dermopathy).
    When to see a doctor:
    Many of these symptoms can be caused by other conditions. If you experience persistent or concerning symptoms that might suggest a thyroid problem, it’s important to see a healthcare provider. A simple blood test can often help determine if your symptoms are related to your thyroid.

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Ali1234Researcher

How many types of thyroid are there?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:19 am

    While there is only one thyroid gland, there are several types of thyroid conditions or diseases that can affect its function. These can be broadly categorized into two main types based on hormone production: * Hypothyroidism (Underactive Thyroid): This occurs when the thyroid gland doesn't produceRead more

    While there is only one thyroid gland, there are several types of thyroid conditions or diseases that can affect its function. These can be broadly categorized into two main types based on hormone production:
    * Hypothyroidism (Underactive Thyroid): This occurs when the thyroid gland doesn’t produce enough thyroid hormones.
    * Common causes include:
    * Hashimoto’s thyroiditis: An autoimmune disorder where the body’s immune system attacks and damages the thyroid gland.
    * Iodine deficiency
    * Certain medications
    * Post-surgical or radiation treatment of the thyroid
    * Congenital hypothyroidism (present at birth)
    * Hyperthyroidism (Overactive Thyroid): This occurs when the thyroid gland produces too much thyroid hormone.
    * Common causes include:
    * Graves’ disease: An autoimmune disorder where the immune system stimulates the thyroid to produce excess hormones.
    * Toxic adenomas (nodules that overproduce hormones)
    * Thyroiditis (inflammation of the thyroid that can temporarily cause excess hormone release)
    Besides these two main categories, other common thyroid conditions include:
    * Goiter: An enlargement of the thyroid gland, which can be caused by both hyper- or hypothyroidism, or iodine deficiency.
    * Thyroid Nodules: Lumps or growths in the thyroid gland, which are usually benign (non-cancerous) but can sometimes be cancerous or cause hormone imbalances.
    * Thyroiditis: Inflammation of the thyroid gland, which can cause temporary hyperthyroidism followed by hypothyroidism. Examples include postpartum thyroiditis, subacute thyroiditis, and silent thyroiditis.
    * Thyroid Cancer: Malignant growth of cells in the thyroid gland. There are different types, such as papillary, follicular, medullary, and anaplastic.
    So, while there are two primary classifications (hypo- and hyperthyroidism), there are various underlying conditions and diseases that fall under the umbrella of “thyroid problems.”

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Ali1234Researcher

What is thyroid?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:16 am

    The thyroid is a butterfly-shaped gland located at the front of your neck, just below your Adam's apple. It's a vital part of your endocrine (hormonal) system. What does the thyroid do? The main function of the thyroid gland is to produce and release hormones that regulate your body's metabolism, grRead more

    The thyroid is a butterfly-shaped gland located at the front of your neck, just below your Adam’s apple. It’s a vital part of your endocrine (hormonal) system.
    What does the thyroid do?
    The main function of the thyroid gland is to produce and release hormones that regulate your body’s metabolism, growth, and development. These hormones, primarily triiodothyronine (T3) and thyroxine (T4), act like messengers that influence nearly every cell and organ system in your body.
    Here’s a breakdown of its key roles:
    * Metabolism: Thyroid hormones control your metabolic rate, which is how quickly your body uses energy from food. This affects things like:
    * How fast you burn calories
    * Your body temperature
    * Heart rate
    * Digestive function
    * Growth and Development: Especially in children, thyroid hormones are crucial for proper brain development and overall physical growth.
    * Other Body Functions: Thyroid hormones also play a role in:
    * Muscle function
    * Bone maintenance
    * Nervous system activity (affecting mood, memory, and reflexes)
    * Skin, hair, and eye health
    * Fertility and menstruation
    The thyroid gland also produces another hormone called calcitonin, which helps regulate calcium levels in your blood.
    How is thyroid hormone production regulated?
    The production of thyroid hormones is a finely tuned process controlled by the pituitary gland (located in your brain) and the hypothalamus (another brain region). The pituitary gland releases Thyroid-Stimulating Hormone (TSH), which tells the thyroid gland how much T3 and T4 to produce. If there’s too little thyroid hormone in the blood, the pituitary releases more TSH, and if there’s too much, it releases less.
    Common Thyroid Disorders:
    Problems with the thyroid gland can lead to various conditions, including:
    * Hypothyroidism (underactive thyroid): Occurs when the thyroid doesn’t produce enough hormones, slowing down your metabolism. Symptoms can include fatigue, weight gain, cold intolerance, and dry skin.
    * Hyperthyroidism (overactive thyroid): Occurs when the thyroid produces too many hormones, speeding up your metabolism. Symptoms can include irritability, anxiety, weight loss, and a fast heartbeat.
    * Goiter: An enlargement of the thyroid gland, often caused by iodine deficiency.
    * Thyroiditis: Inflammation of the thyroid gland.
    * Thyroid nodules: Lumps in the thyroid gland, which can be benign or cancerous.

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Ali1234Researcher

Important questions related to the thyroid that women need to know the answers to

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:15 am

    Thyroid disorders are significantly more common in women than in men and can have a profound impact on various aspects of a woman's health throughout her life. Here are important questions related to the thyroid that women need to know the answers to: 1. What does the thyroid gland do and why is itRead more

    Thyroid disorders are significantly more common in women than in men and can have a profound impact on various aspects of a woman’s health throughout her life. Here are important questions related to the thyroid that women need to know the answers to:
    1. What does the thyroid gland do and why is it important for women?
    The thyroid is a butterfly-shaped gland located at the base of your neck. It produces hormones (thyroxine or T4, and triiodothyronine or T3) that regulate your metabolism, energy levels, body temperature, heart rate, and almost every organ in your body. For women, these hormones also play a critical role in:
    * Reproductive health: Affecting menstrual cycles, ovulation, and fertility.
    * Pregnancy: Essential for healthy fetal development and maternal well-being.
    * Bone health: Too much thyroid hormone can lead to bone loss (osteoporosis).
    * Emotional and mental health: Imbalances can cause mood swings, depression, and cognitive issues.
    2. What are the common types of thyroid disorders in women?
    The two main types are:
    * Hypothyroidism (underactive thyroid): The thyroid gland doesn’t produce enough hormones. This is the most common thyroid disorder in women.
    * Hyperthyroidism (overactive thyroid): The thyroid gland produces too much hormone.
    3. What are the symptoms of an underactive thyroid (hypothyroidism) in women?
    Symptoms often develop slowly and can be non-specific, making them easy to confuse with other conditions. They include:
    * Fatigue and low energy
    * Weight gain (even with diet and exercise)
    * Feeling cold (cold intolerance)
    * Depressed mood, irritability, or mood swings
    * Menstrual irregularities (heavy, prolonged, or irregular periods)
    * Hair thinning or loss, dry skin, brittle nails
    * Constipation
    * Muscle aches, tenderness, stiffness, and joint pain
    * “Brain fog” or difficulty concentrating
    * Slowed heart rate
    4. What are the symptoms of an overactive thyroid (hyperthyroidism) in women?
    Symptoms of hyperthyroidism can include:
    * Unexplained weight loss
    * Anxiety, nervousness, and irritability
    * Rapid or irregular heartbeat (palpitations)
    * Increased sweating and heat intolerance
    * Tremors (shaking hands)
    * Frequent bowel movements or diarrhea
    * Menstrual irregularities (lighter or infrequent periods)
    * Muscle weakness
    * Sleep problems (insomnia)
    * Goiter (enlargement of the thyroid gland in the neck)
    * Eye changes (bulging eyes in Graves’ disease)
    5. How does thyroid health affect fertility and pregnancy?
    Thyroid hormone levels are crucial for healthy reproductive function.
    * Infertility: Both hypothyroidism and hyperthyroidism can disrupt ovulation, making it difficult to conceive.
    * Pregnancy risks: Untreated thyroid conditions during pregnancy can lead to:
    * Increased risk of miscarriage
    * Preeclampsia
    * Preterm birth
    * Low birth weight
    * Developmental issues in the baby (including cognitive impairments)
    * Placental abruption
    * Postpartum thyroiditis: Some women may experience thyroid problems after giving birth.
    It’s vital for women who are trying to conceive or are pregnant to have their thyroid function monitored closely.
    6. When should a woman get her thyroid checked?
    * If you experience persistent symptoms associated with thyroid dysfunction (as listed above).
    * If you have a family history of thyroid disorders.
    * During pregnancy or if you are planning to become pregnant.
    * As part of routine health check-ups, especially as you age, as thyroid dysfunction becomes more common after menopause.
    7. How are thyroid conditions diagnosed?
    Diagnosis typically involves:
    * Blood tests: Measuring Thyroid Stimulating Hormone (TSH), and sometimes T4 and T3 levels. TSH is often the first test to indicate a problem.
    * Physical examination: Checking for goiter or other signs.
    * Antibody tests: To identify autoimmune thyroid conditions like Hashimoto’s thyroiditis (common cause of hypothyroidism) or Graves’ disease (common cause of hyperthyroidism).
    8. What are the treatment options for thyroid disorders in women?
    Treatment depends on the type and severity of the condition:
    * Hypothyroidism: Usually treated with daily thyroid hormone replacement medication (levothyroxine).
    * Hyperthyroidism: Treatment options include anti-thyroid medications, radioactive iodine therapy, or surgery (thyroidectomy) in some cases. Beta-blockers may be used for symptom management.
    9. What can women do to maintain thyroid health?
    While not all thyroid conditions are preventable, certain lifestyle choices can support thyroid health:
    * Balanced diet: Rich in iodine (e.g., iodized salt, fish, dairy), selenium (e.g., Brazil nuts, tuna, eggs), and zinc. Avoid excessive intake of iodine.
    * Stress management: Chronic stress can negatively impact thyroid function. Practice techniques like yoga, meditation, or deep breathing.
    * Regular exercise: Helps maintain a healthy weight and can improve thyroid function.
    * Sufficient sleep: Aim for 7-9 hours of quality sleep.
    * Limit exposure to environmental toxins: Certain chemicals and pollutants can interfere with thyroid function.
    * Avoid processed foods and excessive sugar.
    * Regular check-ups and medication adherence: If diagnosed with a thyroid condition, consistent monitoring and taking prescribed medication as directed are crucial.
    By understanding these key aspects, women can be more proactive about their thyroid health and seek timely medical attention if they suspect a problem.

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Ali1234Researcher
In: China, India, Russia

Trade arms, 'disappointment with Trump' and Russia: Is India trying to improve relations with China?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:12 am

    India's foreign policy is complex and driven by its desire for strategic autonomy. While there are signs of India attempting to stabilize or even improve relations with China, it's not a straightforward move and is influenced by various factors, including its relationship with the US and Russia. HerRead more

    India’s foreign policy is complex and driven by its desire for strategic autonomy. While there are signs of India attempting to stabilize or even improve relations with China, it’s not a straightforward move and is influenced by various factors, including its relationship with the US and Russia.
    Here’s a breakdown of the factors at play:
    1. “Disappointment with Trump” and its impact on China relations:
    * Trade Tensions with the US: The current US administration under Donald Trump has employed trade leverage against India, imposing tariffs and pushing for specific trade deals. This has created some friction and a sense of unpredictability in the US-India relationship.
    * Shifting US Focus: Some analyses suggest that Trump’s approach might be leading India to reassess its full alignment with the US, particularly if the US is perceived as an unreliable partner or if its policies are detrimental to India’s economic interests. This could indirectly push India to explore better ties with other major powers, including China.
    * Hedging Bets: India, like many countries, seeks to diversify its partnerships to avoid over-reliance on any single nation. A challenging relationship with the US under Trump could lead India to strategically “hedge its bets” by seeking rapprochement with China.
    2. India’s Approach to China:
    * Border Disputes Remain Central: Despite efforts to de-escalate, the long-standing and often tense border disputes, particularly along the Line of Actual Control (LAC), remain a significant obstacle to full normalization of ties. India consistently emphasizes the need for de-escalation on the border as a prerequisite for progress in bilateral relations.
    * Economic Interdependence: China has been India’s largest trading partner for many years, leading to significant economic interdependence. India faces a large trade deficit with China. While there have been efforts to reduce reliance on Chinese imports, economic realities often necessitate continued engagement.
    * Strategic Rivalry: India views China’s growing influence in South Asia and the Indian Ocean Region, including its strong ties with Pakistan, as a major security concern. China’s Belt and Road Initiative (BRI) is also a point of contention for India.
    * Recent Thaw, but with Caution: There have been recent diplomatic engagements, including India’s External Affairs Minister’s visit to China. This signals a cautious attempt to improve relations and find areas of cooperation, especially on global issues. However, India is clear that contentious bilateral issues, like the border dispute, must be addressed.
    3. Trade Arms and Russia’s Role:
    * Long-standing Russia-India Ties: India has a deep and historic defense relationship with Russia, relying on it for a significant portion of its military equipment. Russia has been a reliable supplier of arms and has been willing to share technology and co-produce weapons with India, unlike some Western nations.
    * Strategic Autonomy: India’s continued strong ties with Russia, despite US objections, are a testament to its commitment to strategic autonomy. India views Russia as a crucial source of arms and energy, and a key member of international groupings like BRICS and SCO where both India and China are members.
    * Russia as a Bridge? Russia has an interest in maintaining good relations with both India and China. While Russia’s increasing dependence on China due to Western sanctions might complicate this, there’s a possibility that Russia could, in some contexts, facilitate dialogue or cooperation between India and China, for example, within forums like the RIC (Russia-India-China) troika.
    In conclusion:
    India is not necessarily “trying to improve relations with China” in a way that suggests a full alignment or a shift away from its other partnerships. Instead, it’s pursuing a strategy of “multi-alignment” or “strategic autonomy” in a complex geopolitical landscape.
    * The “disappointment with Trump” administration’s unpredictable policies and trade pressures might be prompting India to explore ways to reduce its vulnerability by diversifying its relationships.
    * While a full resolution of the border dispute with China remains elusive and a major impediment, India is seeking to stabilize the relationship and find common ground on global issues.
    * India’s enduring defense ties with Russia are a critical component of its strategic autonomy and indirectly influence its balancing act between the US and China.
    Ultimately, India’s foreign policy is about protecting its national interests, securing its borders, and enhancing its global standing in a multipolar world. This often involves a delicate balancing act and pragmatic engagement with all major powers.

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Ali1234Researcher
In: India, oil, Russia

Cheap oil imports from Russia and Trump's threat: Can India stop trade with its old ally under American pressure?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:11 am

    India faces a complex balancing act between its historical strategic partnership with Russia, including significant defense ties and discounted oil imports, and the potential economic repercussions of US secondary sanctions threatened by the current US administration. Here's a breakdown of the situaRead more

    India faces a complex balancing act between its historical strategic partnership with Russia, including significant defense ties and discounted oil imports, and the potential economic repercussions of US secondary sanctions threatened by the current US administration.
    Here’s a breakdown of the situation:
    1. India’s Reliance on Russian Oil:
    * Since the Ukraine conflict began in February 2022, India has significantly increased its imports of discounted Russian oil, which now accounts for approximately one-third of its total oil imports, compared to less than 1% before the war. This has been a pragmatic economic decision for India, a major oil importer.
    * Indian refiners have been able to process this discounted crude into refined products like diesel and jet fuel, some of which have been re-exported, including to Europe.
    2. Trump’s Threat of Secondary Sanctions:
    * President Trump has announced a threat of 100% tariffs on Russian exports, including oil, and an “equivalent secondary tariff” on countries importing Russian shipments. This threat comes with a 50-day deadline for Russia to end the war in Ukraine.
    * Crucially, these proposed secondary tariffs, unlike previous ones, could apply to all merchandise exports from a country, not just entities directly dealing with sanctioned Russian entities. This could severely impact India’s $45.7 billion trade surplus with the US, affecting key sectors like textiles, pharmaceuticals, electronics, and IT services.
    * US senators have also proposed even more severe tariffs, potentially up to 500%, on imported goods from countries that continue to purchase Russian oil, gas, and other products.
    * NATO’s Secretary General has also warned India, China, and Brazil about potential secondary sanctions for their continued commercial relations with Russia.
    3. India’s Response and Options:
    * Official Stance: India’s Oil Minister Hardeep Singh Puri has stated confidence in India’s ability to meet its energy requirements, even if Russian oil imports face sanctions or secondary tariffs. He indicated that alternative supplies are available globally, albeit at a higher cost.
    * Economic Impact: While Russian oil offers discounts, the potential cost of tariffs on India’s merchandise exports to the US could far outweigh these benefits. Indian refiners might be forced to revert to traditional West Asian suppliers and explore new sources like Brazil, which would likely lead to higher import costs.
    * Strategic Maneuvering: Some Indian oil industry officials interpret Trump’s threat as a negotiation tactic, suggesting it might have minimal actual impact on global oil trade or India’s Russian crude purchases. India and the US are also in ongoing discussions for a bilateral trade deal, and imposing such tariffs could derail these negotiations.
    * Adaptation: Indian refiners might consider segregating their output, using Russian oil for domestic sales or Asian exports, and sourcing from other nations for European markets, though this would not be seamless.
    4. India’s Strategic Relationship with Russia:
    * Beyond oil, India and Russia share a “special and privileged strategic partnership” with deep historical roots, particularly in defense, civil nuclear energy, and anti-terrorism cooperation. Russia remains a crucial supplier of defense equipment to India.
    * Both countries are members of BRICS, G20, and SCO, and Russia supports India’s bid for a permanent seat on the UN Security Council.
    Can India stop trade with its old ally under American pressure?
    It’s a difficult decision for India. Completely halting trade with Russia, especially oil imports, would be a significant economic and strategic shift.
    * Pressure to Comply: The threat of broad secondary tariffs targeting all of India’s exports to the US is a powerful economic leverage. Given the significant volume of trade between India and the US, and India’s aspirations for a trade deal, the pressure is substantial.
    * Maintaining Strategic Autonomy: India highly values its strategic autonomy and non-alignment. Yielding completely to US pressure might be seen as compromising this principle and abandoning a long-standing ally.
    * Finding a Balance: India will likely seek to navigate this situation by exploring options that minimize economic damage while attempting to maintain its strategic relationships. This could involve gradually reducing dependence on Russian oil, diversifying its import sources, and emphasizing its own national interests in energy security.
    Ultimately, India’s decision will be a careful calculation of economic costs, strategic imperatives, and its commitment to maintaining a multi-aligned foreign policy in a complex geopolitical landscape.

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Ali1234Researcher

October 12, 1999: Did Karachi Police try to arrest General Musharraf?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:08 am

    On October 12, 1999, Pakistani Prime Minister Nawaz Sharif attempted to dismiss General Pervez Musharraf as Chief of Army Staff while Musharraf was returning to Pakistan from a trip to Sri Lanka. As part of this attempt to remove him, orders were given to prevent Musharraf's plane from landing at KaRead more

    On October 12, 1999, Pakistani Prime Minister Nawaz Sharif attempted to dismiss General Pervez Musharraf as Chief of Army Staff while Musharraf was returning to Pakistan from a trip to Sri Lanka. As part of this attempt to remove him, orders were given to prevent Musharraf’s plane from landing at Karachi’s Quaid-i-Azam International Airport.
    There were indeed instructions for his arrest. Prosecution witnesses in the subsequent “plane hijacking case” stated that the then Inspector General of Police, Rana Maqbool, had ordered the arrest of the army chief as soon as the plane landed, even directing an SSP from Nawabshah City to carry out the arrest if the plane was diverted there.
    However, the military, loyal to Musharraf, quickly mobilized. Army commanders took control of key government institutions, including the Karachi airport control tower, effectively thwarting any attempt by Karachi police or other authorities to arrest Musharraf upon his arrival. Instead, it was Nawaz Sharif and his administration who were placed under house arrest, and Musharraf subsequently seized power in a bloodless coup.

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Ali1234Researcher

What is Daratumumab and how is it used?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:06 am

    Daratumumab, also known by the brand name Darzalex, is a targeted cancer drug classified as a monoclonal antibody. It is primarily used to treat multiple myeloma, a cancer of plasma cells found in the bone marrow. How it Works (Mechanism of Action) Daratumumab works by targeting a specific protein cRead more

    Daratumumab, also known by the brand name Darzalex, is a targeted cancer drug classified as a monoclonal antibody. It is primarily used to treat multiple myeloma, a cancer of plasma cells found in the bone marrow.
    How it Works (Mechanism of Action)
    Daratumumab works by targeting a specific protein called CD38, which is abundantly present on the surface of multiple myeloma cells. By binding to CD38, daratumumab initiates several anti-cancer mechanisms:
    * Direct cell death (apoptosis): It can directly induce myeloma cell death.
    * Immune system activation: It recruits various immune cells to destroy the cancer cells:
    * Complement-dependent cytotoxicity (CDC): It activates the complement system, a part of the immune system that can directly kill cells.
    * Antibody-dependent cell-mediated cytotoxicity (ADCC): It tags cancer cells for destruction by natural killer (NK) cells.
    * Antibody-dependent cellular phagocytosis (ADCP): It signals macrophages to engulf and destroy the cancer cells.
    * Immune modulation: It can also help to decrease immune system suppression, allowing the body’s own defenses to work more effectively against the cancer.
    How it is Used
    Daratumumab is administered by a healthcare provider, either as an intravenous (IV) infusion (into a vein) or a subcutaneous injection (under the skin). The dosing schedule varies depending on the specific regimen and whether it’s used as a single therapy or in combination with other drugs.
    It is used in various scenarios for multiple myeloma:
    * Newly diagnosed multiple myeloma: Often in combination with other standard treatments (e.g., bortezomib, melphalan, prednisone, thalidomide, lenalidomide, dexamethasone), both for patients who are eligible or ineligible for autologous stem cell transplant.
    * Relapsed or refractory multiple myeloma: For patients whose cancer has returned or has not responded to previous therapies, sometimes as a single agent (monotherapy) or in combination with other medications.
    Common Side Effects
    Like all medications, daratumumab can cause side effects. Some common side effects include:
    * Infusion-related reactions: These can occur during or shortly after administration and may include symptoms like cough, headache, nausea, chills, chest tightness, or shortness of breath. Pre- and post-infusion medications are often given to help prevent these reactions.
    * Low blood cell counts: This can include a decrease in white blood cells (increasing infection risk) and platelets (increasing bleeding risk).
    * Upper respiratory tract infections (cold-like symptoms)
    * Fatigue
    * Diarrhea or constipation
    * Peripheral neuropathy (nerve damage causing tingling, numbness, or pain)
    * Swelling (e.g., in hands, ankles, or feet)
    It’s important for patients to discuss any side effects or concerns with their healthcare provider.

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Ali1234Researcher
In: Pakistan

What disease does Pervez Musharraf have?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:05 am

    Pervez Musharraf suffered from amyloidosis, a rare disease where an abnormal protein called amyloid builds up in organs and tissues throughout the body, hindering their proper function. He had been undergoing treatment for this condition since at least March 2016 and passed away in 2023 due to complRead more

    Pervez Musharraf suffered from amyloidosis, a rare disease where an abnormal protein called amyloid builds up in organs and tissues throughout the body, hindering their proper function. He had been undergoing treatment for this condition since at least March 2016 and passed away in 2023 due to complications from it.

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Ali1234Researcher
In: Pakistan

Pervez Musharraf's return to Pakistan: What is the medicine that the former president cannot get in Pakistan?

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  1. Ali1234 Researcher
    Added an answer on July 22, 2025 at 8:00 am

    Pervez Musharraf suffered from a rare condition called Amyloidosis. His family stated that an uninterrupted supply and administration of the experimental drug Daratumumab, needed alongside associated treatment for Amyloidosis, was not available in Pakistan. This was a key reason cited by his familyRead more

    Pervez Musharraf suffered from a rare condition called Amyloidosis. His family stated that an uninterrupted supply and administration of the experimental drug Daratumumab, needed alongside associated treatment for Amyloidosis, was not available in Pakistan.
    This was a key reason cited by his family for his inability to return to Pakistan for treatment, and he remained in Dubai where he eventually passed away in February 2023.

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